ABSTRACT
Distal symmetrical polyneuropathy and neuromuscular weakness is common neurological problem in recovery phase of acute organophosphate (OP) poisoning. Various types of extra pyramidal syndromes are uncommon sequel after OP poisoning. These are reported to be reversible within few weeks and characteristically associated with normal magnetic resonance imaging (MRI). In this report we are presenting a case with extra pyramidal syndrome after acute OP poisoning with few interesting MRI changes in striatum.
Subject(s)
Adult , Basal Ganglia Diseases/chemically induced , Dichlorvos/poisoning , Female , Humans , Insecticides/poisoning , Magnetic Resonance Imaging , Neostriatum/physiology , Organophosphorus Compounds/poisoningABSTRACT
A case of organophosphorous poisoning in a 29 year old male who developed intermediate syndrome manifested by features of respiratory depression as evidenced by marked weakness of the respiratory muscles, tachypnoea, and drop in oxygen saturation despite reversal of nicotinic and muscarinic effects of organophosphorous poisoning. The case highlights its early recognition and prompt institution of mechanical ventilation with continuation of anticholinergic drugs. The mechanical ventilation had to be continued for 9 days with successful outcome.
Subject(s)
Adult , Cholinesterase Inhibitors/poisoning , Dichlorvos/poisoning , Humans , Male , Pesticides/poisoning , Respiratory Insufficiency/chemically induced , Suicide, Attempted , SyndromeSubject(s)
Adult , Atropine/therapeutic use , Cholinesterase Inhibitors/poisoning , Cholinesterase Reactivators/therapeutic use , Dichlorvos/poisoning , Female , Humans , Insecticides/poisoning , Male , Monocrotophos/poisoning , Muscarinic Antagonists/pharmacology , Neurotoxicity Syndromes/physiopathology , Organophosphorus Compounds/poisoning , Pralidoxime Compounds/therapeutic use , Suicide, AttemptedABSTRACT
Cholinesterase (ChE) activity in the blood serum of rats was elevated to 15, 25, and 45 times by the sc administration of 1000, 2000 and 3000 electric eel acetylcholinesterase (AChE) units respectively. Apparently no ill-effect to animals was observed. The maximal activity of the enzyme occurred in 90 min after its administration and was directly proportional to the administered dose. The increase activity of ChE in the serum on the exogenous administration of AChE persisted for 18 hr. The exogenously raised serum ChE, protected rats against lethal dose of dichlorvos, but not against lethal dose of soman. The possible mechanism of differential response in discussed.
Subject(s)
Acetylcholinesterase/pharmacokinetics , Animals , Cholinesterases/blood , Dichlorvos/poisoning , Dose-Response Relationship, Drug , Male , Poisoning/prevention & control , Rats , Rats, Wistar , Soman/poisoningABSTRACT
Neurological complications like type II paralysis are well described in organophosphorus poisoning. Sphincteric involvement is not described. We report two patients of organophosphorus poisoning who had sphincteric involvement as an unusual manifestation of type II paralysis.